The main reason that science has declined - that it has become absolutely, not just relatively immune from any form of evidence, including evidence of its own corruption and careerism - is that professional science no longer believes in reality.
Science (scientists) no longer believe that reality is real, no longer believe that there really is a reality underneath all of the peer review, bureaucracy, consensus, and competitions for status, security and salary; punditry and prizes...
Or, if some individual 'scientists' do believe that reality is real, then they do not see reality as important; they do not see themselves (qua scientist) as having a duty to reality - a non-negotiable and bounden duty to seek-for and speak only this reality - so far as they best understand it.
They simply don't feel this.
For modern 'scientists', reality is just one of the options.
So, the root of the problem is that science is nihilistic (nihilism means the belief that there is no reality).
It is the unbelief in reality which allows science to be, to any extent which is expedient, untruthful - non-truth-seeking.
Because science is only self-correcting when scientists believe in reality, want to know about it, and believe they must always be truthful about what they (think they) know.
When scientists believe in reality and are motivated to seek the truth about it, then science will work.
That is all that is needed.
Therefore real science is very, very simple.
Questions of scientific methods are irrelevant, questions of organization are irrelevant - such real scientists will find a way.
But, since the pre-requisites are rare (not many reality-based people are truly truth-seeking and truthful), and the pressures for corruption are so strong, that real science is both rare and fragile.
When scientists do not believe in reality and are not bound by truth; then the fact that all methods are selective and biased approximations and there is always wriggle-room and loopholes; and when science is done in (scientist-choosing) organizations instead of (scientist-chosen) alliances - these mean that the door is opened to limitless deception (of the self, and of others).
So.... here we are!